| Molecular Formula | C14H12N2O4S2 |
| Molar Mass | 336.39 |
| Density | 1.43±0.1 g/cm3(Predicted) |
| Boling Point | 378.1±42.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| Appearance | paste |
| Color | white to beige |
| pKa | 11.25±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 2 months. |
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.973 ml | 14.864 ml | 29.728 ml |
| 5 mM | 0.595 ml | 2.973 ml | 5.946 ml |
| 10 mM | 0.297 ml | 1.486 ml | 2.973 ml |
| 5 mM | 0.059 ml | 0.297 ml | 0.595 ml |
| biological activity | CBR-5884 is a selective inhibitor of phosphoglycerate dehydrogenase (PHGDH), the corresponding IC50 value was 33 μm. CBR-5884 inhibits de novo Serine Synthesis in cancer cells and is selectively toxic to cancer cells with homoserine biosynthetic activity. |
| Target | TargetValue PHGDH (Cell-free assay) 33 μm |
| Target | Value |
| PHGDH (Cell-free assay) | 33 μM |